De novo diabetes mellitus in kidney allografts: nodular sclerosis and diffuse glomerulosclerosis leading to graft failure.
نویسندگان
چکیده
Key words: de novo diabetic diffuse glomerulosclerosis; The patient's graft functioned well (mean serum creatinine of 124 mmol/l) and her fasting glucose was de novo diabetic nodular glomerulosclerosis; post-transplant diabetes mellitus; renal transplant normal (range 3.8–5.2 mmol/l) during the first 7 months after surgery. Immunosuppression consisted of cyclosporin 12 mg/kg/day and subsequently the dose was adjusted aiming at a whole-blood trough level of
منابع مشابه
Early recurrence of diabetic nodular sclerosis in a kidney transplant recipient.
Almost all kidney transplant recipients with diabetes mellitus will eventually develop recurrence of diabetic nephropathy in their allograft. Despite this high incidence, there are very few reported cases of diabetic nephropathy of diffuse type, and the nodular sclerosis form is uncommon. Recurrence of diabetic nephropathy of nodular glomerulosclerosis type usually occurs during the second deca...
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tissue contained 15 glomeruli with diffuse thickening Introduction of the glomerular basement membrane as well as increase in mesangial matrix in each. In addition, Nodular glomerulosclerosis is a well-described lesion mesangial hyaline nodular lesions were present in seven of diabetic nephropathy. Although it was considered glomeruli (Figure 1). No tubulointerstitial or vascular pathognomonic ...
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A 53-year-old woman with a history of dyslipidemia presented with medium-grade proteinuria and several years of progressive renal dysfunction. Renal biopsy showed diffuse and global Kimmelstiel-Wilson nodule like nodular mesangial sclerosis, but she had no history of diabetes mellitus, no diabetic retinopathy and normal oral glucose tolerance. Congo red staining was negative, and immunofluoresc...
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INTRODUCTION Diabetic nephropathy can occur during the course of both type1 and type 2 diabetes mellitus. The characteristic lesions are diffuse or nodular (Kimmelsteil-Wilson) diabetic glomerulosclerosis. The reported cases represent unusual presentations of diabetes mellitus. CASE PRESENTATION We report the case of a 49-year-old man without prior history of diabetes mellitus who presented w...
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BACKGROUND Nodular glomerulosclerosis is seen in insulin dependent diabetic patients with nephropathy. Kimmelstiel-Wilson nodules on biopsy are considered pathognomonic. Diabetic nephropathy is a spectrum of glomerular and tubular disease which correlates with the duration of the diabetes and the extent of glycaemic control. CASE REPORT An eleven year old girl with cystic fibrosis was referre...
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ورودعنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 14 8 شماره
صفحات -
تاریخ انتشار 1999